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BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity.

Immunity - 15 Sept 2015

Fransen Floris, Zagato Elena, Mazzini Elisa, Fosso Bruno, Manzari Caterina, El Aidy Sahar, Chiavelli Andrea, D'Erchia Anna Maria, Sethi Maya K, Pabst Oliver, Marzano Marinella, Moretti Silvia, Romani Luigina, Penna Giuseppe, Pesole Graziano, Rescigno Maria

Abstract excerpt

The interrelationship between IgAs and microbiota diversity is still unclear. Here we show that BALB/c mice had higher abundance and diversity of IgAs than C57BL/6 mice and that this correlated with increased microbiota diversity. We show that polyreactive IgAs mediated the entrance of non-invasive bacteria to Peyer's patches, independently of CX3CR1(+) phagocytes. This allowed the induction of bacteria-specific...

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Identifiers

PMID: 26362264
DOI: 10.1016/j.immuni.2015.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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