Article
Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice.
Gastroenterology - 1 Mar 2001
Veltkamp C, Tonkonogy S L, De Jong Y P, Albright C, Grenther W B, Balish E, Terhorst C, Sartor R B
Abstract excerpt
BACKGROUND & AIMS: Normal resident bacteria are required for development of colitis in several rodent models. We determined whether bacterial stimulation is necessary for both induction and perpetuation of mucosal inflammation and T-cell activation in Tg(epsilon26) mice, in which transplantation of wild-type bone marrow (BM-->Tg(epsilon26)) causes colitis under specific pathogen-free (SPF) conditions. METHODS: BM...
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