Article
IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer's Patches of Mice.
Frontiers in immunology - 1 Jan 2021
Ullrich Leon, Lueder Yvonne, Juergens Anna-Lena, Wilharm Anneke, Barros-Martins Joana, Bubke Anja, Demera Abdi, Ikuta Koichi, Patzer Gwendolyn Elena, Janssen Anika, Sandrock Inga, Prinz Immo, Rampoldi Francesca
Abstract excerpt
The mucosal immune system is the first line of defense against pathogens. Germinal centers (GCs) in the Peyer's patches (PPs) of the small intestine are constantly generated through stimulation of the microbiota. In this study, we investigated the role of γδ T cells in the GC reactions in PPs. Most γδ T cells in PPs localized in the GCs and expressed a TCR composed of Vγ1 and Vδ6 chains. By using mice with...
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