Article
Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation.
Nature - 7 May 2015
Moon Clara, Baldridge Megan T, Wallace Meghan A, D Carey-Ann, Burnham, Virgin Herbert W, Stappenbeck Thaddeus S
Abstract excerpt
The proliferation of genetically modified mouse models has exposed phenotypic variation between investigators and institutions that has been challenging to control. In many cases, the microbiota is the presumed cause of the variation. Current solutions to account for phenotypic variability include littermate and maternal controls or defined microbial consortia in gnotobiotic mice. In conventionally raised mice,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.