Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low-frequency HIV-1 drug resistance mutations can be clinically significant but must be interpreted with caution.

The Journal of antimicrobial chemotherapy - 1 Jul 2010

Johnson Jeffrey A, Geretti Anna Maria

Abstract excerpt

With drug-resistant HIV-1 present in at least 10%-20% of new infections in Western countries and in >60% of patients failing antiretroviral therapy (ART), monitoring HIV-1 drug resistance is becoming increasingly important for assessing its impact on therapeutic measures of virus control and for guiding treatment. The sensitivity limitations of conventional bulk genotyping often lead to an underestimation of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to DNA Fingerprinting
Share to Drug Monitoring

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to HIV Infections

Share to Mutation, Missense

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 20466851
DOI: 10.1093/jac/dkq139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-frequency HIV-1 drug resistance mutations can be clinically significant but must be interpreted with caution.PMID 20466851Read ↗

Simple PCR assays improve the sensitivity of HIV-1 subtype B drug resistance testing and allow linking of resistance mutations.Semantic proximity Read ↗

Longitudinal Detection and Persistence of Minority Drug-Resistant Populations and Their Effect on Salvage Therapy.Semantic proximity Read ↗

Minority variants of drug-resistant HIV.Semantic proximity Read ↗

Transmission of HIV drug resistance: lessons from sensitive screening assays.Semantic proximity Read ↗

Next-generation sequencing reveals major and minority HIV-1 drug resistance mutations in treatment-experienced individuals with virological failure.Semantic proximity Read ↗

The Role of HIV-1 Drug-Resistant Minority Variants in Treatment FailureSemantic proximity Read ↗

Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naïve populations and associate with reduced treatment efficacy.Semantic proximity Read ↗

Primary HIV-1 Drug Resistant Minority Variants.Semantic proximity Read ↗

Reliability and Clinical Relevance of the HIV-1 Drug Resistance Test in Patients With Low Viremia LevelsSemantic proximity Read ↗

An observational study of high- and low-abundance anti-retroviral resistance mutations among treatment-naïve people living with HIV in New Zealand between 2012 and 2017.Semantic proximity Read ↗

Low-Abundance Drug-Resistant HIV-1 Variants in Antiretroviral Drug-Naive Individuals: A Systematic Review of Detection Methods, Prevalence, and Clinical Impact.Semantic proximity Read ↗

HIV resistance testing: methods, utility, and limitations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.