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Article

Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly destabilizing epileptogenic mutation.

Journal of cell science - 1 Nov 2015

Alberdi Araitz, Gomis-Perez Carolina, Bernardo-Seisdedos Ganeko, Alaimo Alessandro, Malo Covadonga, Aldaregia Juncal, Lopez-Robles Carlos, Areso Pilar, Butz Elisabeth, Wahl-Schott Christian, Villarroel Alvaro

Abstract excerpt

We show that the combination of an intracellular bi-partite calmodulin (CaM)-binding site and a distant assembly region affect how an ion channel is regulated by a membrane lipid. Our data reveal that regulation by phosphatidylinositol(4,5)bisphosphate (PIP2) and stabilization of assembled Kv7.2 subunits by intracellular coiled-coil regions far from the membrane are coupled molecular processes. Live-cell...

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PMID: 26359296
DOI: 10.1242/jcs.176420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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