Article
Cooperativity between calmodulin-binding sites in Kv7.2 channels.
Journal of cell science - 1 Jan 2013
Alaimo Alessandro, Alberdi Araitz, Gomis-Perez Carolina, Fernández-Orth Juncal, Gómez-Posada Juan Camilo, Areso Pilar, Villarroel Alvaro
Abstract excerpt
Among the multiple roles assigned to calmodulin (CaM), controlling the surface expression of Kv7.2 channels by binding to two discontinuous sites is a unique property of this Ca(2+) binding protein. Mutations that interfere with CaM binding or the sequestering of CaM prevent this M-channel component from exiting the endoplasmic reticulum (ER), which reduces M-current density in hippocampal neurons, enhancing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.