Article
Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin.
Structure (London, England : 1993) - 4 Nov 2014
Sachyani Dana, Dvir Meidan, Strulovich Roi, Tria Giancarlo, Tobelaim William, Peretz Asher, Pongs Olaf, Svergun Dmitri, Attali Bernard, Hirsch Joel A
Abstract excerpt
Kv7 channels tune neuronal and cardiomyocyte excitability. In addition to the channel membrane domain, they also have a unique intracellular C-terminal (CT) domain, bound constitutively to calmodulin (CaM). This CT domain regulates gating and tetramerization. We investigated the structure of the membrane proximal CT module in complex with CaM by X-ray crystallography. The results show how the CaM intimately hugs...
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