Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2.

The Journal of biological chemistry - 15 Dec 2006

Mei Zhu-Zhong, Xia Rong, Beech David J, Jiang Lin-Hua

Abstract excerpt

TRPM2 channels, activated by adenosine diphosphoribose and related molecules, are assembled as oligomers and most likely tetramers. However, the molecular determinants driving the subunit interaction and assembly of the TRPM2 channels are not well defined. Here we examined, using site-directed mu...

Topics

Base Sequence
Cell Line
DNA Primers
Humans
Immunoprecipitation
Mutation
TRPM Cation Channels

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17060318
DOI: 10.1074/jbc.M607591200
PMCID: PMC1698503

Genes

TRPM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17060318-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2.PMID 17060318Read ↗

Coiled coils direct assembly of a cold-activated TRP channel.Semantic proximity Read ↗

Conserved cysteine residues in the pore region are obligatory for human TRPM2 channel function.Semantic proximity Read ↗

Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly destabilizing epileptogenic mutation.Semantic proximity Read ↗

Structure of the receptor-activated human TRPC6 ion channelSemantic proximity Read ↗

Structural and molecular basis of the assembly of the TRPP2/PKD1 complexSemantic proximity Read ↗

Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.Semantic proximity Read ↗

Structural domains required for channel function of the mouse transient receptor potential protein homologue TRP1beta.Semantic proximity Read ↗

Macromolecular complexes of cystic fibrosis transmembrane conductance regulator and its interacting partnersSemantic proximity Read ↗

A conserved Cys-loop receptor aspartate residue in the M3-M4 cytoplasmic loop is required for GABAA receptor assembly.Semantic proximity Read ↗

Pas de deux in groups of four--the biogenesis of KATP channels.Semantic proximity Read ↗

P2X5 Subunit Assembly Requires Scaffolding by the Second Transmembrane Domain and a Conserved AspartateSemantic proximity Read ↗

Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.