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Article

Intracellular coiled-coil domain engaged in subunit interaction and assembly of melastatin-related transient receptor potential channel 2.

The Journal of biological chemistry - 15 Dec 2006

Mei Zhu-Zhong, Xia Rong, Beech David J, Jiang Lin-Hua

Abstract excerpt

TRPM2 channels, activated by adenosine diphosphoribose and related molecules, are assembled as oligomers and most likely tetramers. However, the molecular determinants driving the subunit interaction and assembly of the TRPM2 channels are not well defined. Here we examined, using site-directed mutagenesis in conjunction with co-immunoprecipitation and patch clamp recording, the role of a coiled-coil domain in the...

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Identifiers

PMID: 17060318
DOI: 10.1074/jbc.M607591200
PMCID: PMC1698503

Genes

TRPM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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