Article

An Epilepsy-Causing Mutation Leads to Co-Translational Misfolding

2020-11-26

Abstract excerpt

Protein folding to the native state is particularly relevant in human diseases where inherited mutations lead to structural instability, aggregation and degradation. In general, the amino acid sequence carries all the necessary information for the native conformation, but the vectorial nature of translation can determine the folding outcome. Calmodulin (CaM) recognizes the properly folded Calcium Responsive Domain...

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Literature Corpus work: be899573-181a-5669-8ab5-e5c722cb1aab
DOI: 10.1101/2020.11.25.398222

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