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Article

An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Sept 2015

Sevgi Meltem, Rigoux Lionel, Kühn Anne B, Mauer Jan, Schilbach Leonhard, Hess Martin E, Gruendler Theo O J, Ullsperger Markus, Stephan Klaas Enno, Brüning Jens C, Tittgemeyer Marc

Abstract excerpt

Variations in the fat mass and obesity-associated (FTO) gene are linked to obesity. However, the underlying neurobiological mechanisms by which these genetic variants influence obesity, behavior, and brain are unknown. Given that Fto regulates D2/3R signaling in mice, we tested in humans whether variants in FTO would interact with a variant in the ANKK1 gene, which alters D2R signaling and is also associated with...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 26354923
DOI: 10.1523/JNEUROSCI.1589-15.2015
PMCID: PMC6605390

Genes

FTO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An Obesity-Predisposing Variant of the FTO Gene Regulates D2R-Dependent Reward Learning.PMID 26354923Read ↗

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