Article
Association of the fat mass and obesity-associated gene risk allele, rs9939609A, and reward-related brain structures.
Obesity (Silver Spring, Md.) - 1 Oct 2015
de Groot Corjan, Felius Abraham, Trompet Stella, de Craen Anton J M, Blauw Gerard J, van Buchem Mark A, Delemarre-van de Waal Henriette A, van der Grond Jeroen
Abstract excerpt
OBJECTIVE: Recently, the fat mass and obesity-associated gene (FTO) has been identified as a genetic risk factor for developing obesity. The underlying mechanisms remain speculative. SNPs within FTO have been associated with brain atrophy in frontal and occipital regions, suggesting that FTO might affect body weight through cerebral pathways. Behavioral studies suggested a relationship between FTO and the...
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