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Article

Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity.

Diabetologia - 1 Dec 2016

Heni Martin, Kullmann Stephanie, Ahlqvist Emma, Wagner Robert, Machicao Fausto, Staiger Harald, Häring Hans-Ulrich, Almgren Peter, Groop Leif C, Small Dana M, Fritsche Andreas, Preissl Hubert

Abstract excerpt

AIMS/HYPOTHESIS: Variations in FTO are the strongest common genetic determinants of adiposity, and may partly act by influencing dopaminergic signalling in the brain leading to altered reward processing that promotes increased food intake. Therefore, we investigated the impact of such an interaction on body composition, and peripheral and brain insulin sensitivity. METHODS: Participants from the Tübingen Family...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27600277
DOI: 10.1007/s00125-016-4095-0

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity.PMID 27600277Read ↗

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