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Article

Increased meso-striatal connectivity mediates trait impulsivity in FTO variant carriers.

Frontiers in endocrinology - 1 Jan 2023

Edwin Thanarajah Sharmili, Hanssen Ruth, Melzer Corina, Tittgemeyer Marc

Abstract excerpt

Objective: While variations in the first intron of the fat mass and obesity-associated gene (FTO, rs9939609 T/A variant) have long been identified as a major contributor to polygenic obesity, the mechanisms underlying weight gain in risk allele carriers still remain elusive. On a behavioral level, FTO variants have been robustly linked to trait impulsivity. The regulation of dopaminergic signaling in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37223038
DOI: 10.3389/fendo.2023.1130203
PMCID: PMC10200952

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