A link between FTO, ghrelin, and impaired brain food-cue responsivity.

doi:10.1172/JCI44403

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Article

A link between FTO, ghrelin, and impaired brain food-cue responsivity.

The Journal of clinical investigation - 1 Aug 2013

Karra Efthimia, O'Daly Owen G, Choudhury Agharul I, Yousseif Ahmed, Millership Steven, Neary Marianne T, Scott William R, Chandarana Keval, Manning Sean, Hess Martin E, Iwakura Hiroshi, Akamizu Takashi, Millet Queensta, Gelegen Cigdem, Drew Megan E, Rahman Sofia, Emmanuel Julian J, Williams Steven C R, Rüther Ulrich U, Brüning Jens C, Withers Dominic J, Zelaya Fernando O, Batterham Rachel L

Abstract excerpt

Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with human obesity and obesity-prone behaviors, including increased food intake and a preference for energy-dense foods. FTO demethylates N6-methyladenosine, a potential regulatory RNA modification, but the mechanisms by which FTO predisposes humans to obesity remain unclear. In adiposity-matched, normal-weight humans, we showed that...

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PMID: 23867619
DOI: 10.1172/JCI44403
PMCID: PMC3726147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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