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Article

Association of ABCB1, ABCC5 and xanthine oxidase genetic polymorphisms with methotrexate adverse reactions in Mexican pediatric patients with ALL.

Drug metabolism and personalized therapy - 1 Sept 2015

Zaruma-Torres Fausto, Lares-Asseff Ismael, Reyes-Espinoza Aarón, Loera-Castañeda Verónica, Chairez-Hernández Isaías, Sosa-Macías Martha, Galaviz-Hernández Carlos, Almanza-Reyes Horacio

Abstract excerpt

BACKGROUND: Acute lymphoblastic leukemia (ALL) is one of the most frequent oncological disorders in pediatric populations. To date, the drug of choice for the treatment of ALL is methotrexate, a drug associated with a high risk of adverse reactions (ADRs). The xanthine oxidase (XO) polymorphisms, 1936A>G and 2107A>G, as well as the polymorphic variants derived from ATP-binding cassette transporter gene...

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Topics

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Share to Antimetabolites, Antineoplastic
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Maintenance Chemotherapy

Share to Methotrexate

Share to Multidrug Resistance-Associated Proteins

Share to Myelopoiesis

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Xanthine Oxidase

Source

Identifiers

PMID: 26353179
DOI: 10.1515/dmpt-2015-0011

Genes

ABCC5
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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