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Article

Effect of polymorphisms in transporter genes on dosing, efficacy and toxicity of maintenance therapy in children with acute lymphoblastic leukemia.

Gene - 10 Sept 2017

Gervasini Guillermo, de Murillo Silvia G, Jiménez Mercedes, de la Maya María D, Vagace Jose M

Abstract excerpt

The aim of the present work was to assess whether polymorphisms in genes coding for drug transport proteins may influence dosing, efficacy and toxicity of maintenance therapy with methotrexate (MTX) and 6-mercaptopurine (6MP) in childhood acute lymphoblastic leukemia (ALL). A total of 41 children with ALL were screened for 10 SNPs in the SLC19A1, ABCB1, ABCC2, ABCC4 and ABCG2 transporter genes by means of direct...

Read the complete abstract on PubMed

Topics

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Share to Antimetabolites, Antineoplastic
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Mercaptopurine

Share to Methotrexate

Share to Multidrug Resistance-Associated Protein 2

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Reduced Folate Carrier Protein

Source

Identifiers

PMID: 28710036
DOI: 10.1016/j.gene.2017.07.025

Genes

ABCC4
ABCB1
ABCC2
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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