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Evaluation of cytogenetic and molecular markers with MTX-mediated toxicity in pediatric acute lymphoblastic leukemia patients.

Cancer chemotherapy and pharmacology - 1 Mar 2022

Ramalingam Ravi, Kaur Harpreet, Scott Julius Xavier, Sneha Latha M, Arunkumar Ganeshprasad, Srinivasan Arathi, Paul Solomon F D

Abstract excerpt

PURPOSE: Pediatric acute lymphoblastic leukemia (pALL) patients have better overall survival and methotrexate (MTX) is an effective drug used in their treatment. However, the treatment-related adverse effects (TRAEs) have a bigger impact on the therapy. In this study, we have evaluated the association of polymorphisms in genes encoding proteins engaged in MTX metabolism, and the cytogenetic aberrations with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35157101
DOI: 10.1007/s00280-022-04405-7

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