Article
Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia.
Genes - 28 May 2020
Kodidela Sunitha, Dorababu Patchava, Thakkar Dimpal N, Dubashi Biswajit, Sundaram Rajan, Muralidharan Niveditha, Nidanapu Ravi Prasad, Aribandi Anil, Pradhan Suresh Chandra, Uppugunduri Chakradhara Rao Satyanarayana
Abstract excerpt
Genetic variants influencing the pharmacokinetics and/or pharmacodynamics of the chemotherapeutic drugs used in Acute Lymphoblastic Leukemia (ALL) therapy often contribute to the occurrence of treatment related toxicity (TRT). In this study, we explored the association of candidate genetic variants with early hematological TRT (grade 3-4) occurring within the first 100 days of low-dose methotrexate and...
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