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Evaluation of Methotrexate Toxicity and its Association with ABCB1 Genetic Polymorphism in Children with Acute Lymphoblastic Leukemia

2022-08-10

Abstract excerpt

<h4>Background: </h4> Acute lymphoblastic leukemia(ALL) is the most common type of hematologic malignancy in children. Based on COG protocol, one of the treatments for these children is methotrexate. Methotrexate has many complications in Pediatrics. Nowadays, the relationship between gene mutations and complications of each drug are discussed. This study aimed to evaluate the pharmacogenetics of methotrexate with...

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Literature Corpus work
b250ff47-24e6-577f-9d03-510054ee1483
DOI
10.21203/rs.3.rs-121087/v2
Open publication

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