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Article

The alg-1 Gene Is Necessary for Orsay Virus Replication in Caenorhabditis elegans.

Journal of virology - 27 Apr 2023

Cubillas Ciro, Sandoval Del Prado Luis Enrique, Goldacker Sydney, Fujii Chika, Pinski Amanda N, Zielke Jon, Wang David

Abstract excerpt

The establishment of the Orsay virus-Caenorhabditis elegans infection model has enabled the identification of host factors essential for virus infection. Argonautes are RNA interacting proteins evolutionary conserved in the three domains of life that are key components of small RNA pathways. C. elegans encodes 27 argonautes or argonaute-like proteins. Here, we determined that mutation of the argonaute-like gene...

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Identifiers

PMID: 37017532
DOI: 10.1128/jvi.00065-23
PMCID: PMC10134801

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