Article

Modeling neurodevelopmental disorder-associated <i>hAGO1</i> mutations in <i>C. elegans</i> Argonaute <i>ALG-1</i>

2023-04-07

Abstract excerpt

<h4>ABSTRACT</h4> MicroRNAs (miRNA) are endogenous non-coding RNAs important for post-transcriptional regulation of gene expression. miRNAs associate with Argonaute proteins to bind to the 3’ UTR of target genes and confer target repression. Recently, multiple de novo coding variants in the human Argonaute gene AGO1 ( hAGO1 ) have been reported to cause a neurodevelopmental disorder (NDD) with intellectual dis...

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Literature Corpus work: 7eb0a239-9e35-528d-8aca-698edf7e6b85
DOI: 10.1101/2023.04.06.535748

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