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Article

Truncated trkB.T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival.

Biochemical and biophysical research communications - 9 Feb 2001

Haapasalo A, Koponen E, Hoppe E, Wong G, Castrén E

Abstract excerpt

Truncated trkB.T1 (T1) neurotrophin receptor inhibits full-length trkB.TK+ (TK+) signaling. At least two possible mechanisms have been proposed for this action: T1 could trap the ligand or function as a dominant negative receptor. To differentiate between these possibilities we have studied survival of serum-deprived PC12-trkB cells stably expressing TK+. PC12-trkB cells were observed to display constitutive trkB...

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Source

Identifiers

PMID: 11162678
DOI: 10.1006/bbrc.2001.4296

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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