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Article

Impaired Ca2+ handling and contraction in cardiomyocytes from mice with a dominant negative thyroid hormone receptor alpha1.

Journal of molecular and cellular cardiology - 1 Apr 2005

Tavi Pasi, Sjögren Maria, Lunde Per Kristian, Zhang Shi-Jin, Abbate Fabio, Vennström Björn, Westerblad Håkan

Abstract excerpt

The profound effects of thyroid hormone (TH) on heart development and function are mediated by the thyroid hormone receptors (TR) alpha(1) and beta(1). While numerous patients with TRbeta(1) mutations have been identified, patients with similar mutations in TRalpha(1) are yet to be discovered. Recently generated heterozygous mice with a dominant negative mutation in TRalpha(1) (TRalpha(1)+/m mice) have normal TH...

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PMID: 15808842
DOI: 10.1016/j.yjmcc.2005.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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