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Article

Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes

10 Oct 2019

Abstract excerpt

Ubiquitylation of outer mitochondrial membrane (OMM) proteins is closely related to the onset of familial Parkinson's disease. Typically, a reduction in the mitochondrial membrane potential results in Parkin-mediated ubiquitylation of OMM proteins, which are then targeted for proteasomal and mitophagic degradation. The role of ubiquitylation of OMM proteins with non-degradative fates, however, remains poorly...

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Share to Autophagy in Disease and Therapy
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PMID: 31602805
DOI: 10.15252/embr.201947728

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