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Article

Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.

Gastroenterology - 1 Dec 2015

Zhao Junjie, Bulek Katarzyna, Gulen Muhammet F, Zepp Jarod A, Karagkounis Georgio, Martin Bradley N, Zhou Hao, Yu Minjia, Liu Xiuli, Huang Emina, Fox Paul L, Kalady Matthew F, Markowitz Sanford D, Li Xiaoxia

Abstract excerpt

BACKGROUND & AIMS: Single immunoglobulin and toll-interleukin 1 receptor (SIGIRR), a negative regulator of the Toll-like and interleukin-1 receptor (IL-1R) signaling pathways, controls intestinal inflammation and suppresses colon tumorigenesis in mice. However, the importance of SIGIRR in human colorectal cancer development has not been determined. We investigated the role of SIGIRR in development of human...

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Identifiers

PMID: 26344057
DOI: 10.1053/j.gastro.2015.08.051
PMCID: PMC5308447

Genes

SIGIRR
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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