Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations.

doi:10.1093/carcin/bgt222

Article

Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations.

Carcinogenesis - 1 Oct 2013

Ingram Nicola, Northwood Emma L, Perry Sarah L, Marston Gemma, Snowden Helen, Taylor John C, Scott Nigel, Bishop D Timothy, Coletta P Louise, Hull Mark A

Abstract excerpt

We investigated the role of interleukin (IL)-4 receptor (IL-4R) signalling during mouse carcinogen-induced colorectal carcinogenesis and in a case-control genetic epidemiological study of IL-4Rα single nucleotide polymorphisms (SNPs). Azoxymethane-induced aberrant crypt focus (ACF; 6 weeks) and tumours (32 weeks) were analysed in wild-type (WT) BALB/c mice, as well as in IL-4Rα (-) (/-) , IL-13 (-/-) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations.

Abstract excerpt

Topics

Related research