Article
SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2022
Yu Wei, Haque Inamul, Venkatraman Aparna, Menden Heather L, Mabry Sherry M, Roy Badal C, Xia Sheng, Prokop Jeremy W, Umar Shahid, Geurts Aron M, Sampath Venkatesh
Abstract excerpt
BACKGROUND & AIMS: Single immunoglobulin interleukin-1-related receptor (SIGIRR) is a major inhibitor of Toll-like receptor signaling. Our laboratory identified a novel SIGIRR stop mutation (p.Y168X) in an infant who died of severe necrotizing enterocolitis (NEC). Herein, we investigated the mechanisms by which SIGIRR mutations induce Toll-like receptor hyper-responsiveness in the neonatal gut, disrupting...
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