Article
The identification of an integral membrane, cytochrome c urate oxidase completes the catalytic repertoire of a therapeutic enzyme.
Scientific reports - 8 Sept 2015
Doniselli Nicola, Monzeglio Enrico, Dal Palù Alessandro, Merli Angelo, Percudani Riccardo
Abstract excerpt
In living organisms, the conversion of urate into allantoin requires three consecutive enzymes. The pathway was lost in hominid, predisposing humans to hyperuricemia and gout. Among other species, the genomic distribution of the two last enzymes of the pathway is wider than that of urate oxidase (Uox), suggesting the presence of unknown genes encoding Uox. Here we combine gene network analysis with association...
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