Article
Cloning and biochemical characterization of three glucose‑6‑phosphate dehydrogenase mutants presents in the Mexican population.
International journal of biological macromolecules - 1 Nov 2018
Cortés-Morales Yadira Yazmín, Vanoye-Carlo America, Castillo-Rodríguez Rosa Angélica, Serrano-Posada Hugo, González-Valdez Abigail, Ortega-Cuellar Daniel, Hernández-Ochoa Beatriz, Moreno-Vargas Liliana Marisol, Prada-Gracia Diego, Sierra-Palacios Edgar, Pérez de la Cruz Verónica, Marcial-Quino Jaime, Gómez-Manzo Saúl
Abstract excerpt
The deficiency of glucose‑6‑phosphate dehydrogenase (G6PD) is one of the most common inborn errors of metabolism worldwide. This congenital disorder generally results from mutations that are spread throughout the entire gene of G6PD. Three single-point mutations for G6PD have been reported in the Mexican population and named Veracruz (Arg365His), G6PD Seattle (Asp282His), and G6PD Mexico DF (Thr65Ala), whose...
Topics
- Circular Dichroism
- Cloning, Molecular
- Enzyme Activation
- Enzyme Stability
- Genetics, Population
- Glucosephosphate Dehydrogenase
- Humans
- Kinetics