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Article

Evidence against resveratrol as a viable therapy for the rescue of defective ΔF508 CFTR.

Biochimica et biophysica acta - 1 Nov 2015

Jai Ying, Shah Kalpit, Bridges Robert J, Bradbury Neil A

Abstract excerpt

BACKGROUND: Resveratrol, a natural phenolic compound, has been reported to rescue mutant ΔF508 CFTR in expression systems and primary epithelial cells. Although this implies a therapeutic benefit to patients with CF, investigations were performed using resveratrol concentrations greatly in excess of those achievable in plasma. We evaluated the efficacy of resveratrol as a CFTR corrector in relevant primary airway...

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Share to Cyclic AMP
Share to Cystic Fibrosis
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26342647
DOI: 10.1016/j.bbagen.2015.08.020
PMCID: PMC4587346

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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