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Article

Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.

The Journal of biological chemistry - 24 Sept 2004

Song Yuanlin, Sonawane N D, Salinas Danieli, Qian Liman, Pedemonte Nicoletta, Galietta Luis J V, Verkman A S

Abstract excerpt

Curcumin, the yellow colored component of the spice turmeric, has been reported to rescue defective DeltaF508-cystic fibrosis transmembrane conductance regulator (CFTR) cellular processing in homozygous mutant mice, restoring nasal potential differences and improving survival (Egan, M. E., Pearso...

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Source

Identifiers

PMID: 15280357
DOI: 10.1074/jbc.M407308200

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15280357-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.PMID 15280357Read ↗

SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis.Semantic proximity Read ↗

Evidence against resveratrol as a viable therapy for the rescue of defective ΔF508 CFTR.Semantic proximity Read ↗

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.Semantic proximity Read ↗

Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers.Semantic proximity Read ↗

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.Semantic proximity Read ↗

Cystic fibrosis transmembrane conductance regulator (CFTR) activity in nasal epithelial cells from cystic fibrosis patients with severe genotypes.Semantic proximity Read ↗

Evidence against defective trans-Golgi acidification in cystic fibrosis.Semantic proximity Read ↗

In vivo activation of the cystic fibrosis transmembrane conductance regulator mutant deltaF508 in murine nasal epithelium.Semantic proximity Read ↗

Arachidonic acid release by ionomycin and phorbol ester is similar in C127 epithelial cells expressing wild-type or mutated (delta F508) cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

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