Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dehydrocostuslactone, a sesquiterpene lactone activates wild-type and ΔF508 mutant CFTR chloride channel.

Journal of Asian natural products research - 1 Jan 2013

Wang Xue, Zhang Yao-Fang, Yu Bo, Yang Shuang, Luan Jian, Liu Xin, Yang Hong

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) represents the main cAMP-activated Cl⁻ channel expressed in the apical membrane of serous epithelial cells. Both deficiency and overactivation of CFTR may cause fluid and salt secretion related diseases. The aim of this study was to ident...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colforsin
Share to Cystic Fibrosis Transmembrane Conductance Regulator
Share to CFTR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lactones

Share to Mutation

Share to Sesquiterpenes

Source

Identifiers

PMID: 23799322
DOI: 10.1080/10286020.2013.804814

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23799322-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dehydrocostuslactone, a sesquiterpene lactone activates wild-type and ΔF508 mutant CFTR chloride channel.PMID 23799322Read ↗

Potentiation of mutant CFTR Cl- channel currents by the naturally occurring stilbene compound resveratrol.Semantic proximity Read ↗

Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease.Semantic proximity Read ↗

[Butyl-p-hydroxybenzoate stimulates cystic fibrosis transmembrane conductance regulator Cl- transport].Semantic proximity Read ↗

CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis.Semantic proximity Read ↗

Potentiation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- currents by the chemical solvent tetrahydrofuran.Semantic proximity Read ↗

Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines.Semantic proximity Read ↗

Receptor-mediated activation of CFTR via prostaglandin signaling pathways in the airway.Semantic proximity Read ↗

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.Semantic proximity Read ↗

Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications.Semantic proximity Read ↗

A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subsetSemantic proximity Read ↗

Cyclic diacyl thioureas enhance activity of corrector Lumacaftor on F508del-CFTR.Semantic proximity Read ↗

Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.