Article
Potentiation of mutant CFTR Cl- channel currents by the naturally occurring stilbene compound resveratrol.
Die Pharmazie - 1 Nov 2013
Yu Bo, Zhang Yaofang, Sui Yujie, Yang Shuang, Luan Jian, Wang Xue, Ma Tonghui, Yang Hong
Abstract excerpt
Previously, we found that the naturally occurring stilbene compound resveratrol (RES) could potentiate cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activity. Because some wild-type CFTR activators also potentiate its mutant forms, we investigated effect of RES on the two most common forms of CF-related mutation (deltaF508 and G551D-CFTR). Cell-based fluorescence studies indicated...
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