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Article

Activation of ΔF508 CFTR in an epithelial monolayer

1 Aug 1998

Abstract excerpt

The DeltaF508 mutation leads to retention of cystic fibrosis transmembrane conductance regulator (CFTR) in the endoplasmic reticulum and rapid degradation by the proteasome and other proteolytic systems. In stably transfected LLC-PK1 (porcine kidney) epithelial cells, DeltaF508 CFTR conforms to this paradigm and is not present at the plasma membrane. When LLC-PK1 cells or human nasal polyp cells derived from a...

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Identifiers

PMID: 9688615
DOI: 10.1152/ajpcell.1998.275.2.c599

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