Article
Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease.
International forum of allergy & rhinology - 1 Jan 2019
Cho Do-Yeon, Zhang Shaoyan, Lazrak Ahmed, Grayson Jessica W, Peña Garcia Jaime A, Skinner Daniel F, Lim Dong Jin, Mackey Calvin, Banks Catherine, Matalon Sadis, Woodworth Bradford A
Abstract excerpt
BACKGROUND: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in defective Cl- transport and cause chronic bacterial infections in the upper and lower airways of cystic fibrosis (CF) patients. Ivacaftor is a CFTR potentiator that improves Cl- transport in CF patients with at least 1 copy of the G551D mutation. Resveratrol is also a potent CFTR potentiator that increases...
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