Article
Resveratrol rescues cAMP-dependent anionic transport in the cystic fibrosis pancreatic cell line CFPAC1.
British journal of pharmacology - 1 Jun 2011
Hamdaoui Nabila, Baudoin-Legros Maryvonne, Kelly Mairead, Aissat Abdel, Moriceau Sandra, Vieu Diane-Lore, Colas Julien, Fritsch Janine, Edelman Aleksander, Planelles Gabrielle
Abstract excerpt
BACKGROUND AND PURPOSE: The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent chloride channel in the plasma membrane of epithelia whose mutation is the cause of the genetic disease cystic fibrosis (CF). The most frequent CFTR mutation is deletion of Phe(508) and this mutant protein (delF508CFTR) does not readily translocate to the plasma membrane and is rapidly degraded within the...
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