Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.

British journal of pharmacology - 1 Oct 2002

Zegarra-Moran Olga, Romio Leila, Folli Chiara, Caci Emanuela, Becq Frederic, Vierfond Jean-Michel, Mettey Yvette, Cabrini Giulio, Fanen Pascale, Galietta Luis J V

Abstract excerpt

1. This study compares the effect of three chemically unrelated cystic fibrosis transmembrane conductance regulator (CFTR) activators on epithelial cell monolayers expressing the G551D-CFTR mutant. 2. We measured Cl(-) transport as the amplitude of short-circuit current in response to the membrane permeable cAMP analogue 8-(4-chlorophenylthio)adenosine-3'-5'-cyclic monophosphate (CPT-cAMP) alone or in combination...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Epithelial Cells

Share to Genistein

Share to Rats, Inbred F344

Share to Xanthines

Source

Open in PubMed Open full text

Identifiers

PMID: 12359632
DOI: 10.1038/sj.bjp.0704882
PMCID: PMC1573508

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.PMID 12359632Read ↗

Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease.Semantic proximity Read ↗

Influence of cell background on pharmacological rescue of mutant CFTR.Semantic proximity Read ↗

The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor.Semantic proximity Read ↗

Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers.Semantic proximity Read ↗

Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications.Semantic proximity Read ↗

Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004.Semantic proximity Read ↗

The dual phosphodiesterase 3/4 inhibitor RPL554 stimulates rare class III and IV CFTR mutants.Semantic proximity Read ↗

Dehydrocostuslactone, a sesquiterpene lactone activates wild-type and ΔF508 mutant CFTR chloride channel.Semantic proximity Read ↗

[From the laboratory to the clinic: CFTR and the therapeutic options for cystic fibrosis].Semantic proximity Read ↗

The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa.Semantic proximity Read ↗

Resveratrol rescues cAMP-dependent anionic transport in the cystic fibrosis pancreatic cell line CFPAC1.Semantic proximity Read ↗

Effect of genistein on native epithelial tissue from normal individuals and CF patients and on ion channels expressed in Xenopus oocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.