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Article

Generation of cAMP-activated chloride currents by expression of CFTR.

Science (New York, N.Y.) - 8 Feb 1991

Anderson M P, Rich D P, Gregory R J, Smith A E, Welsh M J

Abstract excerpt

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis. In order to evaluate its function, CFTR was expressed in HeLa, Chinese hamster ovary (CHO), and NIH 3T3 fibroblast cells, and anion permeability was assessed with a fluorescence microscopic assay and the whole-cell patch-clamp technique. Adenosine 3',5'-monophosphate (cAMP) increased anion permeability and chloride...

Topics

Animals
Cell Line
Chloride Channels
Chlorides
Cricetinae
Cyclic AMP
Cystic Fibrosis Transmembrane Conductance Regulator
Humans
Membrane Proteins
Mice
Mutation
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

Source

Identifiers

PMID: 1704151
DOI: 10.1126/science.1704151

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1704151-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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