Article

Mitochondrial Ca <sup>2+</sup> uniporter (MCU) variants form plasma-membrane channels

2023-08-02

Abstract excerpt

MCU is widely recognized as a responsible gene for encoding a pore-forming subunit of highly mitochondrial-specific and Ca 2+ -selective channel, mitochondrial Ca 2+ uniporter complex (mtCUC). Here, we report a novel short variant derived from the MCU gene (termed MCU-S) which lacks mitochondria-targeted sequence and forms a Ca 2+ - permeable channel outside of mitochondria. MCU-S was ubiquitously expressed in...

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Literature Corpus work: a3a09a4b-b9aa-5f9c-960a-fadaeb555828
DOI: 10.1101/2023.07.31.551242

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