Article

Encoding of the colorectal cancer metabolic program through MICU2

2023-11-02

Abstract excerpt

<h4>Summary</h4> The mitochondrial Ca 2+ uniporter (MCU) plays crucial role in intramitochondrial Ca 2+ uptake, allowing Ca 2+ -dependent activation of oxidative metabolism. In recent decades, the role of MCU pore-forming proteins has been highlighted in cancer. However, the contribution of MCU-associated regulatory proteins mitochondrial calcium uptake 1 and 2 (MICU1 and MICU2) to pathophysiological condition...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1bbe0d98-e5bf-5e2a-ab6c-ead2fb864130
DOI: 10.1101/2023.10.31.564893

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Encoding of the colorectal cancer metabolic program through MICU2DOI 10.1101/2023.10.31.564893Read

MICU1 drives glycolysis and chemoresistance in ovarian cancer.Semantic proximity Read

Colorectal adenocarcinomas downregulate the mitochondrial Na <sup>+</sup> /Ca <sup>2+</sup> exchanger NCLX to drive metastatic spreadSemantic proximity Read

UCP2 as a Cancer Target through Energy Metabolism and Oxidative Stress ControlSemantic proximity Read

Mitochondrial remodeling in colorectal cancer initiation, progression, metastasis, and therapy: A reviewSemantic proximity Read

A null mutation in MICU2 causes abnormal mitochondrial calcium homeostasis and a severe neurodevelopmental disorder.Semantic proximity Read

Mitochondrial calcium uniporter as biomarker and therapeutic target for breast cancer: Prognostication, immune microenvironment, epigenetic regulation and precision medicineSemantic proximity Read

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific SettingsSemantic proximity Read

Dynamic Control of Mitochondrial Ca2+ Levels as a Survival Strategy of Cancer CellsSemantic proximity Read

Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1Semantic proximity Read

Mitochondria: a crucial factor in the progression and drug resistance of colorectal cancerSemantic proximity Read

Interactomic exploration of LRRC8A in volume-regulated anion channelsSemantic proximity Read

MCUR1–CCDC90B complex is a conserved mitochondrial scaffold regulating metabolic homeostasisSemantic proximity Read