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Article

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.

EMBO reports - 1 Mar 2014

Kamer Kimberli J, Mootha Vamsi K

Abstract excerpt

The mitochondrial uniporter is a selective Ca(2+) channel regulated by MICU1, an EF hand-containing protein in the organelle's intermembrane space. MICU1 physically associates with and is co-expressed with a paralog, MICU2. To clarify the function of MICU1 and its relationship to MICU2, we used gene knockout (KO) technology. We report that HEK-293T cells lacking MICU1 or MICU2 lose a normal threshold for Ca(2+)...

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Source

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Identifiers

PMID: 24503055
DOI: 10.1002/embr.201337946
PMCID: PMC3989696

Genes

MICU1
MICU2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.PMID 24503055Read ↗

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Mitochondrial Ca <sup>2+</sup> uniporter (MCU) variants form plasma-membrane channelsSemantic proximity Read ↗

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