Article
Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.
Molecular cell - 16 Mar 2017
Dong Zhiwei, Shanmughapriya Santhanam, Tomar Dhanendra, Siddiqui Naveed, Lynch Solomon, Nemani Neeharika, Breves Sarah L, Zhang Xueqian, Tripathi Aparna, Palaniappan Palaniappan, Riitano Massimo F, Worth Alison M, Seelam Ajay, Carvalho Edmund, Subbiah Ramasamy, Jaña Fabián, Soboloff Jonathan, Peng Yizhi, Cheung Joseph Y, Joseph Suresh K, Caplan Jeffrey, Rajan Sudarsan, Stathopulos Peter B, Madesh Muniswamy
Abstract excerpt
Ca2+ dynamics and oxidative signaling are fundamental mechanisms for mitochondrial bioenergetics and cell function. The MCU complex is the major pathway by which these signals are integrated in mitochondria. Whether and how these coactive elements interact with MCU have not been established. As an approach toward understanding the regulation of MCU channel by oxidative milieu, we adapted inflammatory and hypoxia...
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