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Article

Molecular basis of EMRE-dependence of the human mitochondrial calcium uniporter

2019-05-14

Abstract excerpt

<h4>ABSTRACT</h4> The mitochondrial uniporter is calcium-activated calcium channel complex critical for cellular signaling and bioenergetics. MCU, the pore-forming subunit of the uniporter, contains two transmembrane domains and is found in all major eukaryotic taxa. In amoeba and fungi, MCU homologs are sufficient to form a functional calcium channel, whereas human MCU exhibits a strict requirement for the metaz...

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Literature Corpus work
26b593f8-f2f8-5e90-962b-aefdd1363743
DOI
10.1101/637918
Open publication

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