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Article

Fgfr1 regulates development through the combinatorial use of signaling proteins.

Genes & development - 1 Sept 2015

Brewer J Richard, Molotkov Andrei, Mazot Pierre, Hoch Renée V, Soriano Philippe

Abstract excerpt

Fibroblast growth factor (Fgf) signaling governs multiple processes important in development and disease. Many lines of evidence have implicated Erk1/2 signaling induced through Frs2 as the predominant effector pathway downstream from Fgf receptors (Fgfrs), but these receptors can also signal through other mechanisms. To explore the functional significance of the full range of signaling downstream from Fgfrs in...

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Share to Embryo, Mammalian
Share to Embryonic Development
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Gene Knock-In Techniques

Share to Intracellular Signaling Peptides and Proteins

Share to Receptor, Fibroblast Growth Factor, Type 1

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Source

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Identifiers

PMID: 26341559
DOI: 10.1101/gad.264994.115
PMCID: PMC4573858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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