Article
Roles of FGF receptors in mammalian development and congenital diseases.
Birth defects research. Part C, Embryo today : reviews - 1 Nov 2003
Coumoul Xavier, Deng Chu-Xia
Abstract excerpt
Four fibroblast growth factor receptors (FGFR1-4) constitute a family of transmembrane tyrosine kinases that serve as high affinity receptors for at least 22 FGF ligands. Gene targeting in mice has yielded valuable insights into the functions of this important gene family in multiple biological processes. These include mesoderm induction and patterning; cell growth, migration, and differentiation; organ formation...
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