Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development.

Biology open - 15 Jul 2023

Clark James F, Soriano Philippe

Abstract excerpt

FGF activation is known to engage canonical signals, including ERK/MAPK and PI3K/AKT, through various effectors including FRS2 and GRB2. Fgfr2FCPG/FCPG mutants that abrogate canonical intracellular signaling exhibit a range of mild phenotypes but are viable, in contrast to embryonic lethal Fgfr2-/- mutants. GRB2 has been reported to interact with FGFR2 through a non-traditional mechanism, by binding to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Development
Share to GRB2 Adaptor Protein
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phosphatidylinositol 3-Kinases

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 37421147
DOI: 10.1242/bio.059942
PMCID: PMC10399203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development.PMID 37421147Read ↗

Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.Semantic proximity Read ↗

FGF signaling regulates development by processes beyond canonical pathways.Semantic proximity Read ↗

Fgfr1 regulates development through the combinatorial use of signaling proteins.Semantic proximity Read ↗

Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.Semantic proximity Read ↗

Generation of an Frs2alpha conditional null allele.Semantic proximity Read ↗

FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus.Semantic proximity Read ↗

Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.Semantic proximity Read ↗

Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis.Semantic proximity Read ↗

Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.Semantic proximity Read ↗

Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.Semantic proximity Read ↗

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.Semantic proximity Read ↗

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.