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Article

Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.

Development (Cambridge, England) - 1 Feb 2006

Hoch Renée V, Soriano Philippe

Abstract excerpt

Fibroblast growth factor receptor 1 (Fgfr1) plays pleiotropic roles during embryonic development, but the mechanisms by which this receptor signals in vivo have not previously been elucidated. Biochemical studies have implicated Fgf receptor-specific substrates (Frs2, Frs3) as the principal mediators of Fgfr1 signal transduction to the MAPK and PI3K pathways. To determine the developmental requirements for...

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PMID: 16421190
DOI: 10.1242/dev.02242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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