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Article

Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.

PloS one - 1 Jan 2015

Leigh-Brown Sarah, Goncalves Angela, Thybert David, Stefflova Klara, Watt Stephen, Flicek Paul, Brazma Alvis, Marioni John C, Odom Duncan T

Abstract excerpt

Phenotypic differences between species are driven by changes in gene expression and, by extension, by modifications in the regulation of the transcriptome. Investigation of mammalian transcriptome divergence has been restricted to analysis of bulk gene expression levels and gene-internal splicing. Using allele-specific expression analysis in inter-strain hybrids of Mus musculus, we determined the contribution of...

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PMID: 26339903
DOI: 10.1371/journal.pone.0137367
PMCID: PMC4560434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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