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Article

Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling law.

Life science alliance - 1 Apr 2022

Zou Xudong, Schaefke Bernhard, Li Yisheng, Jia Fujian, Sun Wei, Li Guipeng, Liang Weizheng, Reif Tristan, Heyd Florian, Gao Qingsong, Tian Shuye, Li Yanping, Tang Yisen, Fang Liang, Hu Yuhui, Chen Wei

Abstract excerpt

Alternative splicing is ubiquitous, but the mechanisms underlying its pattern of evolutionary divergence across mammalian tissues are still underexplored. Here, we investigated the cis-regulatory divergences and their relationship with tissue-dependent trans-regulation in multiple tissues of an F1 hybrid between two mouse species. Large splicing changes between tissues are highly conserved and likely reflect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34969779
DOI: 10.26508/lsa.202101333
PMCID: PMC8739531

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